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KMID : 0385020040200020177
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Korean Journal of Laboratory Animal Science
2004 Volume.20 No. 2 p.177 ~ p.180
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Studies on the Pesticide Amitraz-induced Hypotension
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Kim Jong-Choon
Kim Seong-Ho
Kim Jae-Ha
Shin Dong-Ho
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Abstract
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Amitraz is a formamidine pesticide widely used in veterinary medicine. It can produce various side effects that resemble those of the α2-adrenoceptor agonists, such as xylazine and clonidine. In an attempt to explain some of its side effects, the hypotensive effect of amitraz was studied in urethane anesthetized rabbits. The intravenous injection of amitraz (0.5~2.0 mg/kg) to anesthetized rabbits caused a dose-dependent fall in blood pressure. The hypotensive effect of amitraz (1 mg/kg) was significantly prevented by the pretreatment of both yohimbine (2.0 mg/kg, i.v.) and atropine (2.0 mg/kg, i.v.), but not by the pretreatment of dl-propranolol (1 mg/kg, i.v.). The results obtained in the present study suggest that α2-adrenoceptor mediates amitraz-induced hypotensive effects and amitraz also cause the hypotensive effect through an increased cholinergic activity.
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KEYWORD
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Amitraz, Hypotensive effect, Anesthetized rabbits
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